Adaptation of BTITN5B1-4 (High Five) Insect Cells for Large-Scale Production in a Stirred Bioreactor

Adaptation of BTI-TN5B1-4 (high five) insect cells for large-scale production in a stirred bioreactor.

A Facile and Green Synthesis Route for the Production of Silver Nanoparticles in Large Scale

   In the present work, a fast, green and simple synthesis method for the production of silver nanoparticles (AgNPs) is introduced. Silver nanoparticles are currently among the most widely used man-made nano materials, present in a wide range of consumer products. Green chemistry is characterized by careful planning of chemical synthesis of silver nanoparticles to reduce adverse outcomes. S...

A re-usable wave bioreactor for protein production in insect cells

Wave-mixed bioreactors have increasingly replaced stainless steel stirred tank reactors in seed inoculum productions and mammalian cell-based process developments. Pre-sterilized, single-use plastic bags are used for cultivation, eliminating the risk of cross-contamination and cleaning procedures. However, these advantages come with high consumable costs which is the main barrier to more uptake...

Plant cells technology as an effective biotechnological approach for high scale production of pharmaceutical natural compounds; A meta-analysis study

Natural-based drugs are the important bioactive substances that have been used for prevention and treatment of diseases. Natural products should be prepared in commercial scale from relevant medicinal plants. Hence, large amounts of the plants have been needed for extraction and isolation of compounds of natural origin. Plant cells technology is the best strategy for the production of the plant...

Human Papillomavirus Type16- L1 VLP Production in Insect Cells

  Objective(s):  Infection by high-risk papillomavirus is regarded as the major risk factor in the development of cervical cancer. Recombinant DNA technology allows expression of the L1 major capsid protein of HPV in different expression systems, which has intrinsic capacity to self-assemble into viral-like particles (VLP). VLPS are non-infectious, highly immunogenic and can elicit neutralizing...